Department of Pharmacology and Toxicology
RESEARCH
Department of Pharmacology and Toxicology conducts research and development works in the four fields within which following research streams/topics can be distinguished:
RESEARCH IN THE FIELD OF IMMUNOPHARMACOLOGY AND IMMUNOLOGY ON:
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the effect of inhalatory and systemic glucocorticosteroid therapy on T lymphocytes in a mouse model of allergic asthma
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the inhibition of nuclear factor κB and blockade of interaction RANK-L/RANK as new targets in allergic asthma treatment & searching for/evaluation of new therapeutic strategies for the treatment of allergic asthma,
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the possibility of pharmacological induction of regulatory cells,
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the effect of selected immunomodulatory agents on canine T cells,
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the presence and phenotype of T lymphocytes in the eye chambers of animals.
RESEARCH IN THE FIELD OF THE PHARMACOLOGY OF SMOOTH MUSCLE TISSUE ON THE EFFECT OF:
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selected biological active substances on the contractility of uterine smooth muscle of pigs in the luteal phase and early pregnancy,
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flavonoids and bisphenols on the contractile activity of uterine smooth muscle depending on the hormonal status,
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selected neuropeptides on the contractile activity of the bladder.
RESEARCH IN THE FIELD OF THE PHARMACOKINETICS:
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the influence of food and ions on the absorption and pharmacokinetics of tetracyclines and fluoroquinolones in poultry,
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mechanisms of the gastrointestinal absorption and distribution of tetracyclines in humans and animals,
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pharmacological modification of the mechanisms of tetracycline absorption from the gastrointestinal tract,
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determining the pharmacokinetics of selected antibiotics in patients with renal replacement therapy,
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the influence of filters used in dialysis on the concentration of selected antimicrobials in the filtering system.
RESEARCH IN THE FIELD OF THE TOXICOLOGY:
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the assessment of the contamination of the natural environment with pesticides and heavy metals based on the levels of these xenobiotics in plant and animal tissues,
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the interaction of elements and pesticides on the animal body,
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an oxidative stress and its role in the body after exposure of animals to various xenobiotics (with particular emphasis on pesticides commonly available in plant protection and drugs widely used in human and veterinary medicine).
